High Selenium Yeast 1200
SelenoExcell® High Selenium Yeast 1200 is a selenium-enriched yeast and is the closest food-form of selenium available as a supplement. It is trusted by leading academic and health institutions.
SelenoExcell is the first selenium yeast product to achieve Generally Recognized as Safe or GRAS status in food. There are also Qualified Health Claims for selenium. This GRAS designation means SelenoExcell can be used across different functional food and beverage categories, including fruit juices, medical foods, grain products and pasta, baked goods, and milk products.
The independent GRAS conclusion for use of SelenoExcell in infant formula has been notified to FDA and is pending review. The FDA mandated selenium to be included in infant formula in 2019.
Selenium is an essential nutrient for humans. This trace element is a constituent of over two dozen selenoproteins, with roles in DNA synthesis, thyroid hormone metabolism, reproduction, and immune health and oxidative stress.1, ‡
What is SelenoExcell®?
SelenoExcell® is an organically-bound high selenium yeast originating from a non-pathogenic, non-GMO Saccharomyces cerevisiae yeast strain. During its growth, it creates compounds resembling food forms of selenium, similar to those found in Brazil nuts, eggs, peas, and meats. ‡
The S. cerevisiae cells in SelenoExcell® are inactive, and only the nutritional properties remain. The cells cannot reproduce in the human body when consumed because they are no longer alive. ‡
SelenoExcell®'s yeast fermentation process replicates the natural course in which plants absorb and transform minerals from the soil into a more bioavailable form, supporting the nutrition and health potential of selenium. The yeast accumulates, encouraging the incorporation of selenium into the protein structure, supporting antioxidant properties that may reduce oxidative stress in the body. ‡
Research and testing comparing SelenoExcell® to other non-food forms of selenium suggest potential positive impacts.10
What is High Selenium Yeast?
High selenium yeast is a selenium supplement derived from the cultivation of the Saccharomyces cerevisiae yeast strain. Yeast cells absorb selenium and transform it into selenomethionine, a form of selenium that is naturally present in food. 2
Research shows that high selenium yeast exhibits lower toxicity and exhibits higher digestibility, absorption, and retention than other forms of selenium. 3, 4
Selenium is an essential mineral, providing antioxidant, immune system, and thyroid hormone support. 1, 5, ‡
Selenium is nutritionally essential for humans, and is mandated by the FDA for inclusion in infant formulas in the U.S. 6
The results of this clinical study support: 7
Total Cancer Mortality 7
Total Cancer 7
Prostate Cancer 7
Lung Cancer 7
Colon Cancer 7
Further research and clinical trials support the potential positive impacts of selenium supplementation for cancer status. 8, 9, 10, 11, ‡
SelenoExcell®’s extensive testing and research against other non-food forms of selenium suggests significant positive effects in regard to immune support, maternal health, brain function, and thyroid health. ‡
Potential health claims for SelenoExcell® high selenium yeast include:
May act as an antioxidant and free radical scavenger, protecting cells from oxidative stress 10, ‡
May support production of sperm and enhance sperm quality12, ‡
May provide immune function support 13, ‡
Lower toxicity and higher in digestibility, absorption, and retention than other forms of selenium 3, 4, ‡
Applications for SelenoExcell®
What Additional Nutrients are Present in SelenoExcell®?
During fermentation, the yeast creates a rich B-vitamin profile including:
SelenoExcell mineral content also includes phosphorous, potassium, magnesium, and sulfur.
The protein formed during the fermentation process provides beneficial amino acids, including methionine (selenomethionine), threonine, lysine, isoleucine, leucine, valine, and histidine.
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*FDA Qualified Health Claim: Selenium may reduce the risk of certain cancers. Some scientific evidence suggests that consumption of selenium may reduce the risk of certain forms of cancer. However, FDA has determined that this evidence is limited and not conclusive.
‡These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
 Selenium: Fact Sheet for Health Professionals: National Institutes of Health (Accessed May 22, 2023) https://ods.od.nih.gov/factsheets/Selenium-HealthProfessional/
 The use of high-selenium yeast to raise selenium status: how does it measure up? Rayman MP. Br J Nutr. 2004 Oct;92(4):557-73. doi: 10.1079/bjn20041251. PMID: 15522125. (Accessed May 23, 2023) https://pubmed.ncbi.nlm.nih.gov/15522125/
 Digestibility and chemical species of selenium contained in high-selenium yeast. Yoshida M, Sugihara S, Suenaga T, Naito C, Fukunaga K, Tsuchita H.. J Nutr Sci Vitaminol (Tokyo). 2002 Oct;48(5):401-4. doi: 10.3177/jnsv.48.401. PMID: 12656215. (Accessed May 23, 2023) https://pubmed.ncbi.nlm.nih.gov/12656215/
 Bioconversion of inorganic selenium to less toxic selenium forms by microbes: A review. Xingling Nie, et al. Front. Bioeng. Biotechnol., March 13, 2023 Volume 11-2023 doi: 10.3389/fbioe.2023.1167123 (Accessed May 23, 2023) https://www.frontiersin.org/articles/10.3389/fbioe.2023.1167123/full
 Selenium: Fact Sheet for Consumers: National Institutes for Health (Accessed May 23, 2023) https://ods.od.nih.gov/factsheets/Selenium-Consumer/
 Selenium fortification of infant formulas: does selenium form matter? Lönnerdal B, Vargas-Fernández E, Whitacre M. Food Funct. 2017 Nov 15;8(11):3856-3868. doi: 10.1039/c7fo00746a. PMID: 28991311. (Accessed May 23, 2023) https://pubmed.ncbi.nlm.nih.gov/28991311/
 Clark LC, Combs GF Jr, Turnbull BW, Slate EH, Chalker DK, Chow J, Davis LS, Glover RA, Graham GF, Gross EG, Krongrad A, Lesher JL Jr, Park HK, Sanders BB Jr, Smith CL, Taylor JR. JAMA. 1996 Dec 25;276(24):1957-63. Erratum in: JAMA 1997 May 21;277(19):1520. PMID: 8971064. (Accessed May 23, 2023) https://pubmed.ncbi.nlm.nih.gov/8971064/
 Clark LC, Dalkin B, Krongrad A, Combs GF Jr, Turnbull BW, Slate EH, Witherington R, Herlong JH, Janosko E, Carpenter D, Borosso C, Falk S, Rounder J. Br J Urol. 1998 May;81(5):730-4. doi: 10.1046/j.1464-410x.1998.00630.x. PMID: 9634050. (Accessed May 23, 2023) https://pubmed.ncbi.nlm.nih.gov/9634050/
 Influence of Selenium-enriched Yeast Supplementation on Biomarkers of Oxidative Damage and Hormone Status in Healthy Adult Males Karam El-Bayoumy John P. Richie Telih Boyiri Despina Komninou Bogdan Prokopczyk Neil Trushin Wayne Kleinman Julie Cox Brian Pittman Steven Colosimo; 1 November 2002; 11 (11): 1459–1465. (Accessed May 23, 2023) https://aacrjournals.org/cebp/article/11/11/1459/166657/Influence-of-Selenium-enriched-Yeast
 Comparative effects of two different forms of selenium on oxidative stress biomarkers in healthy men: a randomized clinical trial. Richie JP Jr, Das A, Calcagnotto AM, Sinha R, Neidig W, Liao J, Lengerich EJ, Berg A, Hartman TJ, Ciccarella A, Baker A, Kaag MG, Goodin S, DiPaola RS, El-Bayoumy K. Cancer Prev Res (Phila). 2014 Aug;7(8):796-804. doi: 10.1158/1940-6207.CAPR-14-0042. Epub 2014 Jun 17. PMID: 24938534; PMCID: PMC4125492. (Accessed May 23, 2023) https://pubmed.ncbi.nlm.nih.gov/24938534/
 El-Bayoumy K. Mutat Res. 2001 Apr 18;475(1-2):123-39. doi: 10.1016/s0027-5107(01)00075-6. PMID: 11295158. (Accessed May 23, 2023) https://pubmed.ncbi.nlm.nih.gov/11295158/
 The effect of oral selenium supplementation on human sperm motility. Scott R, MacPherson A, Yates RW, Hussain B, Dixon J. Br J Urol. 1998 Jul;82(1):76-80. doi: 10.1046/j.1464-410x.1998.00683.x. PMID: 9698665. (Accessed May 23, 2023) https://pubmed.ncbi.nlm.nih.gov/9698665/
 The influence of selenium on immune responses. Hoffmann PR, Berry MJ. Mol Nutr Food Res. 2008 Nov;52(11):1273-80. doi: 10.1002/mnfr.200700330. PMID: 18384097; PMCID: PMC3723386. (Accessed May 23, 2023) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723386/