Chromium Picolinate

Fully-Reacted Chelated Mineral

Chromium is a trace mineral that supports metabolization of carbohydrates, fats, and proteins. Chromium picolinate is an absorbable format of this trace mineral, making it a common ingredient in supplements. 1, 2, ‡

Cypress Ingredients chromium picolinate is a fully chelated mineral, making it more easily absorbed by the body. Fully reacted, chelated minerals do not become disassociated in the stomach’s acidic environment. They remain covalently bonded and can be properly absorbed and used by the body.

Fully reacted mineral ingredients, including our chromium picolinate are up to four times more bioavailable, with less inhibition by other minerals, and have fewer potential side effects.


Chromium Picolinate

Chromium is a trace element, naturally available in a range of foods and commonly added to supplements. 1


There are two types of chromium: trivalent (+3) chromium and hexavalent (+6) chromium. Trivalent chromium is the safe and non-toxic format of this mineral. Hexavalent chromium is a toxic by-product of manufacturing and stainless steel processing. 3


Chromium is widely studied for its potential role in enabling insulin action and thereby supporting improved carbohydrate, lipid, and protein metabolism. Chromium is found primarily in the spleen, bones, soft tissue, and liver. 3



Chromium picolinate is an absorbable form of chromium, making it the ideal ingredient format for supplements. 1. ‡

Chromium picolinate is derived by attaching the chromium mineral to three picolinic acid molecules. 2

While there is ongoing research to determine if chromium is an essential mineral, we do know that chromium picolinate has several roles in the body.1, 2, 3, 4

Chromium Picolinate Research Data

Chromium picolinate and chromium are widely researched for their potential health benefits:

  • Understanding the role of chromium picolinate in supporting lipid and carbohydrate metabolism at the molecular level. 5
  • Potential to support lower blood sugar levels for people with diabetes. 6, 7
  • May support the metabolic action of insulin, supporting a reduction in risk factors for cardiovascular conditions for people living with metabolic syndrome and type 2 diabetes. 8

Benefits of Chromium Picolinate

The benefits of chromium picolinate include:

Supporting metabolism of fats, carbohydrates, and proteins

Providing support for more normalized insulin levels

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

[1] Chromium: Fact Sheet for Consumers: National Institutes for Health (Accessed June 5, 2023)

[2] Chromium Picolinate: What Are The Benefits: Healthline (Accessed June 5, 2023)

[3] Chromium: Fact Sheet for Professionals: National Institutes for Health (Accessed June 5, 2023)

[4] Di Bona KR, Love S, Rhodes NR, McAdory D, Sinha SH, Kern N, Kent J, Strickland J, Wilson A, Beaird J, Ramage J, Rasco JF, Vincent JB. Chromium is not an essential trace element for mammals: effects of a “low-chromium” diet. J Biol Inorg Chem. 2011 Mar;16(3):381-90. doi: 10.1007/s00775-010-0734-y. Epub 2010 Nov 18. PMID: 21086001.

[5] John B. Vincent, The Biochemistry of Chromium, The Journal of Nutrition, Volume 130, Issue 4, April 2000, Pages 715–718,

[6] Pei D, Hsieh CH, Hung YJ, Li JC, Lee CH, Kuo SW. The influence of chromium chloride-containing milk to glycemic control of patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled trial. Metabolism. 2006 Jul;55(7):923-7. doi: 10.1016/j.metabol.2006.02.021. PMID: 16784965.

[7] Suksomboon N, Poolsup N, Yuwanakorn A. Systematic review and meta-analysis of the efficacy and safety of chromium supplementation in diabetes. J Clin Pharm Ther. 2014 Jun;39(3):292-306. doi: 10.1111/jcpt.12147. Epub 2014 Mar 17. PMID: 24635480.

[8] Havel PJ. A scientific review: the role of chromium in insulin resistance. Diabetes Educ. 2004;Suppl:2-14. PMID: 15208835.

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