Chromium Picolinate

Fully-Reacted Chelated Mineral

Chromium is a trace mineral that supports metabolization of carbohydrates, fats, and proteins. Chromium picolinate is an absorbable format of this trace mineral, making it a common ingredient in supplements. 1, 2, ‡

Cypress Ingredients chromium picolinate is a fully chelated mineral, making it more easily absorbed by the body. Fully reacted, chelated minerals do not become disassociated in the stomach’s acidic environment. They remain covalently bonded and can be properly absorbed and used by the body.

Fully reacted mineral ingredients, including our chromium picolinate are up to four times more bioavailable, with less inhibition by other minerals, and have fewer potential side effects.


Chromium picolinate is an absorbable form of chromium, making it the ideal ingredient format for supplements. 1. ‡

Chromium picolinate is derived by attaching the chromium mineral to three picolinic acid molecules. 2

While there is ongoing research to determine if chromium is an essential mineral, we do know that chromium picolinate has several roles in the body.1, 2, 3, 4


Chromium Picolinate

Chromium is a trace element, naturally available in a range of foods and commonly added to supplements. 1

There are two types of chromium: trivalent (+3) chromium and hexavalent (+6) chromium. Trivalent chromium is the safe and non-toxic format of this mineral. Hexavalent chromium is a toxic by-product of manufacturing and stainless steel processing. 3

Chromium is widely studied for its potential role in enabling insulin action and thereby supporting improved carbohydrate, lipid, and protein metabolism. Chromium is found primarily in the spleen, bones, soft tissue, and liver. 3

Chromium Picolinate Research Data

Chromium picolinate and chromium are widely researched for their potential health benefits:

  • Understanding the role of chromium picolinate in supporting lipid and carbohydrate metabolism at the molecular level. 5, ‡
  • Potential to support blood sugar levels already within the normal range. 6, 7, ‡
  • May support healthy glucose metabolism and cardiovascualr health. 8, ‡

Applications for Chromium Picolinate

Supplement Capsules on Black 200-2



Supplement Application Gummies on Black 200



Blue tablets pills flu doctor antibiotic pharmacy medicine medical in a bottle on blue wood background



Chocolate bars with nuts filling on black table.


Foods &

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These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

[1] Chromium: Fact Sheet for Consumers: National Institutes for Health (Accessed June 5, 2023)

[2] Chromium Picolinate: What Are The Benefits: Healthline (Accessed June 5, 2023)

[3] Chromium: Fact Sheet for Professionals: National Institutes for Health (Accessed June 5, 2023)

[4] Di Bona KR, Love S, Rhodes NR, McAdory D, Sinha SH, Kern N, Kent J, Strickland J, Wilson A, Beaird J, Ramage J, Rasco JF, Vincent JB. Chromium is not an essential trace element for mammals: effects of a “low-chromium” diet. J Biol Inorg Chem. 2011 Mar;16(3):381-90. doi: 10.1007/s00775-010-0734-y. Epub 2010 Nov 18. PMID: 21086001.

[5] John B. Vincent, The Biochemistry of Chromium, The Journal of Nutrition, Volume 130, Issue 4, April 2000, Pages 715–718,

[6] Pei D, Hsieh CH, Hung YJ, Li JC, Lee CH, Kuo SW.  Metabolism. 2006 Jul;55(7):923-7. doi: 10.1016/j.metabol.2006.02.021. PMID: 16784965.

[7] Suksomboon N, Poolsup N, Yuwanakorn A.  J Clin Pharm Ther. 2014 Jun;39(3):292-306. doi: 10.1111/jcpt.12147. Epub 2014 Mar 17. PMID: 24635480.

[8] Havel PJ. 2004;Suppl:2-14. PMID: 15208835.

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