Magnesium Bisglycinate

Fully-Reacted Chelated Mineral

Magnesium bisglycinate is a highly absorbable and bioavailable form of magnesium, making it an ideal ingredient for supplements. 1, ‡

Magnesium bisglycinate, magnesium glycinate, and magnesium disglycinate are the same mineral. Magnesium bisglycinate is the scientific or chemical name of this form of magnesium.

Cypress Ingredients magnesium bisglycinate is a fully chelated mineral, making it more easily absorbed by the body. Fully reacted, chelated minerals do not become disassociated in the stomach’s acidic environment. They remain covalently bonded and can be properly absorbed and used by the body.

Fully reacted mineral ingredients, including our magnesium bisglycinate are up to four times more bioavailable, with less inhibition by other minerals, and have fewer potential side effects.


Magnesium is an essential mineral involved in over 300 enzyme systems in the human body, including regulating blood sugar levels and blood pressure, muscle and nerve function management, and building protein, bone, and DNA. 2, 3

An estimated 50% of Americans consume less than the recommended daily amount of magnesium, with some populations consuming far less than this. A magnesium deficiency may contribute to a range of conditions including diabetes, metabolic syndrome, cardiovascular challenges, inflammatory reactions, and osteoporosis. Studies have also shown an association between magnesium deficiencies and chronic conditions and the lowering of disease potential with additional magnesium supplementation. 4

People with the following health conditions may not meet recommended magnesium levels: 3

  • Ulcerative colitis, Crohn’s disease, celiac disease, and other gastrointestinal conditions
  • Seniors
  • Long-term alcoholism
  • Type 2 diabetes

    Magnesium bisglycinate is created by binding magnesium with two glycine molecules. This increases the solubility of this essential mineral, making it easily absorbed by the small intestine. 1 ‡

    Magnesium supplementation may have a laxative impact for some people. Because magnesium bisglycinate is bound to glycine, a smaller amount of water attaches to the molecule thereby reducing the laxative properties of this mineral ingredient.

    Magnesium Bisglycinate Research Data

    Magnesium bisglycinate and magnesium are widely recognized for their positive health outcomes:
      • A study of 2,038 men and women between the ages of 70 – 79 found that magnesium supplementation may support higher bone mineral density in some populations. 5
      • A trial involving 210 elderly people with type 2 diabetes and magnesium supplementation was shown to have a positive impact on fat metabolism, mood, and body mass. 6
      • Research into the potential impacts of magnesium supplementation for exercise performance show improvements for both anaerobic and aerobic exercise. 7
      • A study of 4,637 Americans aged 18 – 30 years indicates a potential relationship between magnesium intake and reduced likelihood of metabolic syndrome. 8

      • The National Institute of Health says the following about the importance of magnesium: 2

        “Magnesium is required for energy production, oxidative phosphorylation, and glycolysis. It contributes to the structural development of bone and is required for the synthesis of DNA, RNA, and the antioxidant glutathione.


        Magnesium also plays a role in the active transport of calcium and potassium ions across cell membranes, a process that is important to nerve impulse conduction, muscle contraction, and normal heart rhythm.”

    Recommended Daily Allowance of Magnesium

    The recommended daily allowance (RDA) of magnesium: 2

    • Males aged 31 and older: 420 mg 
    • Females aged 31 and older who are not pregnant: 320 mg 
    • Females aged 31 – 50 who are pregnant: 360 mg 

    Benefits of Magnesium Bisglycinate

    The benefits of magnesium bisglycinate may include: 1, 2, 3, [i]

    • Promotion of bone health
    • Regulation of blood sugar levels for people with diabetes
    • Support for cardiovascular function
    • Improvement of physical exercise performance
    • Carbohydrate, fat, and amino acid metabolism
    • Maintenance of the acid-alkaline balance

    These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

    [1] Everything You Should Know About Magnesium Glycinate: Healthline (Accessed June 8, 2023)

    [2] Magnesium: Fact Sheet for Professionals: National Institutes of Health (Accessed June 8, 2023)

    [3] Magnesium: Fact Sheet for Consumers: National Institutes of Health (Accessed June 8, 2023)

    [4] Costello RB, Elin RJ, Rosanoff A, Wallace TC, Guerrero-Romero F, Hruby A, Lutsey PL, Nielsen FH, Rodriguez-Moran M, Song Y, Van Horn LV. Perspective: The Case for an Evidence-Based Reference Interval for Serum Magnesium: The Time Has Come. Adv Nutr. 2016 Nov 15;7(6):977-993. doi: 10.3945/an.116.012765. PMID: 28140318; PMCID: PMC5105038.

    [5] Ryder KM, Shorr RI, Bush AJ, Kritchevsky SB, Harris T, Stone K, Cauley J, Tylavsky FA. Magnesium intake from food and supplements is associated with bone mineral density in healthy older white subjects. J Am Geriatr Soc. 2005 Nov;53(11):1875-80. doi: 10.1111/j.1532-5415.2005.53561.x. PMID: 16274367.

    [6] Barragán-Rodríguez L, Rodríguez-Morán M, Guerrero-Romero F. Efficacy and safety of oral magnesium supplementation in the treatment of depression in the elderly with type 2 diabetes: a randomized, equivalent trial. Magnes Res. 2008 Dec;21(4):218-23. PMID: 19271419.

    [7] Zhang Y, Xun P, Wang R, Mao L, He K. Can Magnesium Enhance Exercise Performance? Nutrients. 2017 Aug 28;9(9):946. doi: 10.3390/nu9090946. PMID: 28846654; PMCID: PMC5622706.

    [8] He K, Liu K, Daviglus ML, Morris SJ, Loria CM, Van Horn L, Jacobs DR Jr, Savage PJ. Magnesium intake and incidence of metabolic syndrome among young adults. Circulation. 2006 Apr 4;113(13):1675-82. doi: 10.1161/CIRCULATIONAHA.105.588327. Epub 2006 Mar 27. PMID: 16567569.

    [9] Schwalfenberg GK, Genuis SJ. The Importance of Magnesium in Clinical Healthcare. Scientifica (Cairo). 2017;2017:4179326. doi: 10.1155/2017/4179326. Epub 2017 Sep 28. PMID: 29093983; PMCID: PMC5637834.

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