Ferrous Bisglycinate

Fully-Reacted Chelated Mineral

Ferrous bisglycinate is a highly absorbable form of iron that is easier on the digestive system than other forms of iron. 1, ‡

Ferrous bisglycinate, also known as iron bisglycinate, ferrous bisglycinate chelate, ferrous glycinate, and iron glycinate, is the scientific name for this particular form of iron.

Cypress Ingredients ferrous bisglycinate is a fully chelated mineral, increasing its bioavailability in the body. Fully reacted, chelated minerals remain covalently bonded and can be properly absorbed and used by the body. Additionally they do not disassociate in the stomach’s acidic environment.

Fully reacted mineral ingredients, such as our ferrous bisglycinate are up to four times more bioavailable, with less inhibition by other minerals, and have fewer potential side effects.

What is Ferrous Bisglycinate?

Ferrous bisglycinate is a chelated and fully reacted mineral created by binding bivalent iron with two glycine molecules. The chelation process increases the solubility of this supplemental iron, enhancing bioavailability and absorption in the small intestine. Chelated ferrous bisglycinate may be used as part of a treatment approach for iron-deficiency anemia. Ferrous bisglycinate is recognized as being more tolerable than other forms of iron for individuals using supplemental iron. 7, ‡

Ferrous Bisglycinate Research Data

Research on ferrous bisglycinate highlights a range of potential positive health outcomes: 1, 6, 7, 8, 9, ‡

Researchers suggest that because ferrous bisglycinate has better bioavailability than other supplemental forms of iron, it is recommended as a supplement ingredient.

A randomized trial of children aged 1 to 13 years old who were diagnosed with iron-deficiency anemia, were divided into two groups with one group receiving supplemental ferrous bisglycinate and the other group receiving polymaltose iron. The results of this trial showed that while both supplemental iron approaches were successful, the group of children receiving supplemental ferrous bisglycinate had markedly higher ferritin and Mean Corpuscular Hemoglobin levels.

A randomized, controlled trial of two groups of pregnant women (12 – 16 weeks of gestation) were provided with ferrous bisglycinate with folinic acid as multivitamins or with ferrous fumarate. Supplementation with ferrous bisglycinate with folinic acid as a multivitamin showed higher absorption levels, better gastrointestinal tolerance, and overall efficacy than ferrous fumarate.

A systematic review of randomized controlled trials on the effects of ferrous bisglycinate on hemoglobin and ferritin concentration in adults and children showed increased hemoglobin concentrations and fewer gastrointestinal symptoms in pregnant women.

Recommended Daily Allowance of Iron

The recommended daily allowance (RDA) of iron: 2

Males aged 19+: 8 mg

Females aged 19 – 50: 18 mg

Females aged 19 – 50 who are pregnant: 27 mg

Females aged 19 – 50 who are breast feeding: 9 mg

Females aged 51+: 8 mg

Applications for Ferrous Bisglycinate

Supplement Capsules on Black 200-2



Supplement Application Gummies on Black 200



Blue tablets pills flu doctor antibiotic pharmacy medicine medical in a bottle on blue wood background



Chocolate bars with nuts filling on black table.


Foods &

Benefits of Ferrous Bisglycinate

The benefits of ferrous bisglycinate and iron may include: 1, 6, 7, 8, 

Ferrous bisglycinate has higher bioavailability and efficacy than other forms of supplemental iron.

Ferrous bisglycinate shows fewer gastrointestinal symptoms than other supplemental iron.

Iron facilitates the activities of myoglobin and hemoglobin.

Iron is essential to oxygen and carbon dioxide transport through the body.

Iron provides support for energy production and metabolism.

Iron supports fetal development.

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These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

1 Jordie A J Fischer and others, The effects of oral ferrous bisglycinate supplementation on hemoglobin and ferritin concentrations in adults and children: a systematic review and meta-analysis of randomized controlled trials, Nutrition Reviews, Volume 81, Issue 8, August 2023, Pages 904–920. (Accessed July 19, 2023) https://doi.org/10.1093/nutrit/nuac106

2 Iron: Fact Sheet for Health Professionals (Accessed July 19, 2023) https://ods.od.nih.gov/factsheets/Iron-HealthProfessional/

3 Iron: Linus Pauling Institute (Access July 19, 2023) https://lpi.oregonstate.edu/mic/minerals/iron

4 Iron: Fact Sheet for Consumers (Accessed July 19, 2023) https://ods.od.nih.gov/factsheets/Iron-Consumer/

5 Iron-Deficiency Anemia (Accessed July 19, 2023) https://www.hematology.org/education/patients/anemia/iron-deficiency

6 Name JJ, Vasconcelos AR, Valzachi Rocha Maluf MC. Iron Bisglycinate Chelate and Polymaltose Iron for the Treatment of Iron Deficiency Anemia: A Pilot Randomized Trial. Curr Pediatr Rev. 2018;14(4):261-268. doi: 10.2174/1573396314666181002170040. PMID: 30280670; PMCID: PMC6416187. (Accessed July 19, 2023) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416187/

7 Uberti F, Morsanuto V, Ghirlanda S, Molinari C. Iron Absorption from Three Commercially Available Supplements in Gastrointestinal Cell Lines. Nutrients. 2017 Sep 13;9(9):1008. doi: 10.3390/nu9091008. PMID: 28902140; PMCID: PMC5622768. (Accessed July 19, 2023) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622768/

8 Bumrungpert A, Pavadhgul P, Piromsawasdi T, Mozafari MR. Efficacy and Safety of Ferrous Bisglycinate and Folinic Acid in the Control of Iron Deficiency in Pregnant Women: A Randomized, Controlled Trial. Nutrients. 2022 Jan 20;14(3):452. doi: 10.3390/nu14030452. PMID: 35276810; PMCID: PMC8839493. (Accessed July 19, 2023) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839493/

9 A Physician’s Guide to Oral Iron Supplements (Accessed July 19, 2023) https://www.sabm.org/wp-content/uploads/2019/01/2A2-PhysiciansGuideOralIron.pdf