GTF Excell®

Chromium Yeast 600

GTF Excell® Chromium Yeast 600 is a highly bioavailable form of chromium, supporting increased health benefits of chromium. ‡

Glucose Tolerance Factor (GTF) Excell Chromium is a compound used by the liver to manufacture fatty acids, lecithin, cholesterol (HDL), and lipoproteins. Our chromium yeast supplement ingredient also helps manage healthy blood sugar levels, accelerates glucose transport to cells, and stabilizes appetites for healthy weight management. ‡

Chromium is a trace mineral that supports the metabolization of proteins, fats, and carbohydrates. Chromium-enriched yeast extends the potential health benefits of this essential nutrient, due to its enhanced absorbability when compared to other chromium types. 1, ‡
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What is Chromium

Chromium is a trace element, available naturally in food and commonly added to supplements. ‡

Chromium is studied for its possible functions in potentiating insulin activity, thereby supporting improved protein, lipid, and carbohydrate metabolism. Chromium is found in the liver, spleen, soft tissues, and bones. 4 ‡

There are two types of chromium: trivalent (+3) chromium and hexavalent (+6) chromium. Trivalent chromium is the safe and non-toxic format of this mineral. Hexavalent chromium is a toxic by-product of manufacturing and stainless steel processing. 4 ‡
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What is Glucose Tolerance Factor (GTF)?

Glucose tolerance factor (GTF) is the biologically active form of chromium that functions to regulate carbohydrate metabolism and enables insulin activity. GTF chromium yeast originates from Brewer’s yeast and is widely studied for its potential health benefits. 2, 3 ‡

The limitations of the bioavailability of chromium are widely recognized, making the discovery of GTF a game-changer in chromium supplementation and bioavailability. Research reveals that GTF and food-bound chromium may be better absorbed into the body’s tissues, leading to the development of yeast fortified with chromium. This GTF chromium yeast is a more bioavailable form of chromium. ‡

GTF is used by the liver to produce fatty acids, lecithin, cholesterol, and lipoproteins. ‡
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Why Does the Type of Chromium Matter? ‡

The type of chromium matters because chromium absorbability and bioavailability is a challenge for the human body. Simply put, not all types of chromium are equal. ‡

Inorganic chromium salts are associated with a lower bioavailability in tissues and circulation over the long term when compared to food forms of chromium, despite a more rapid rate of initial absorption. ‡

Clinical studies of GTF chromium yeast show potential significant clinical effects at lower doses than in studies using chelated or salt-based chromium. The data indicates that food-form chromium yeast may yield increased levels of absorption of chromium over the long-term, making it a potentially more beneficial form for supplementation. ‡

Our chromium ingredient is bound by a fermentation process with the Saccharomyces cerevisiae yeast strain. This strain of yeast mimics plant metabolization, resulting in a food-form chromium mineral the body can actually absorb. ‡

GTF Excell Chromium Yeast 600 is 20 – 25 times richer in whole food forms of chromium complex than others. ‡
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The Form of Chromium Matters

Chromium Absorption Comparison

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Chromium Yeast
Mertz 1971
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Chromium Picolinate
Gargas 1994
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Chromium Chloride
Mertz 1971

How is GTF Excell Chromium Yeast 600 Formulated? ‡

GTF Excell Chromium Yeast 600 is produced from a non-GMO yeast strain, introducing a chromium salt during active, aseptic, aerobic fermentation. During fermentation, the temperature, pH, and growth rate are closely regulated to assure proper mineral uptake. ‡

The yeast cells take the chromium from the culture medium and organically bind it to their natural protein matrix. The resulting product is washed, separated from its growth media, and held in refrigerated storage to assure cell viability and the absence of any free mineral. ‡

Prior to spray drying, the chilled yeast cream is pasteurized through a high temperature sterilization system to assure it meets or exceeds established USDA food grade microbial requirements. ‡

The composite sample collected during spray drying and packaging is analyzed for nutrient and microbial composition by external, independent, and certified laboratories. Once the product has met all QA/QC requirements, it is released for sale with a supporting Certificate of Analysis. ‡

GTF Chromium Yeast Research Data‡

GTF chromium yeast and chromium are widely studied for their potential health benefits: ‡
  • Research shows that supplementation of chromium-enriched yeast for individuals with well-controlled type 2 diabetes is considered safe and may support beneficial changes in oxidative stress and blood glucose variables. 5
  • Chromium supplementation may support beneficial changes in insulin sensitivity for insulin-resistant individuals. 6
  • Research suggests potential therapeutic applications of GTF for a range of conditions including diabetes mellitus, reactive hypoglycemia, protein malnutrition, hyperlipidemia, obesity, and hypertension. 2
  • May support the metabolic action of insulin, supporting a reduction in risk factors for cardiovascular conditions for people living with metabolic syndrome and type 2 diabetes. 7
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Benefits of GTF Excell Chromium Yeast 600 ‡

  • Supporting healthy blood sugar levels ‡
  • Promoting energy production by accelerating glucose transportation to cells ‡
  • Potential appetite stabilization for healthy weight management ‡
  • Supporting already healthy blood sugar levels ‡
  • Highly bioavailable form of chromium, potentially elevating the health benefits of chromium ‡
‡These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. 

[1] Chromium: Fact Sheet for Consumers: National Institutes for Health (Accessed June 20, 2023) https://ods.od.nih.gov/factsheets/Chromium-Consumer/
[2] McCarty MF. The therapeutic potential of glucose tolerance factor. Med Hypotheses. 1980 Nov;6(11):1177-89. doi: 10.1016/0306-9877(80)90140-1. PMID: 7005627. (Accessed June 20, 2023) https://pubmed.ncbi.nlm.nih.gov/7005627/
[3] Richard A. Anderson, Walter Mertz. “Glucose tolerance factor: an essential dietary agent” Trends in Biochemical Sciences, Volume 2, Issue 12, 1977, Pages 277-279, ISSN 0968-0004. (Accessed June 20, 2023) https://doi.org/10.1016/0968-0004(77)90280-8
[4] Chromium: Fact Sheet for Professionals: National Institutes for Health (Accessed June 20, 2023) https://ods.od.nih.gov/factsheets/Chromium-HealthProfessional/
[5] Racek J, Trefil L, Rajdl D, Mudrová V, Hunter D, Senft V. Influence of chromium-enriched yeast on blood glucose and insulin variables, blood lipids, and markers of oxidative stress in subjects with type 2 diabetes mellitus. Biol Trace Elem Res. 2006 Mar;109(3):215-30. doi: 10.1385/BTER:109:3:215. PMID: 16632892. (Accessed June 20, 2023) https://pubmed.ncbi.nlm.nih.gov/16632892/
[6] Chromium: Examine (Accessed June 20, 2023) https://examine.com/supplements/chromium/research/#zQ64DlA-pharmacology_zQ64DlA-absorption
[7] Havel PJ. A scientific review: the role of chromium in insulin resistance. Diabetes Educ. 2004;Suppl:2-14. PMID: 15208835. (Accessed June 20, 2023) https://pubmed.ncbi.nlm.nih.gov/15208835/