Copper Bisglycinate

Fully-Reacted Chelated Mineral

Copper bisglycinate is a highly absorbable and bioavailable form of the mineral copper, making it the preferred way to supplement copper.

Copper bisglycinate and copper glycinate represent the same mineral. Copper bisglycinate is the scientific or chemical name of this form of copper.

Cypress Ingredients copper bisglycinate is a fully chelated mineral, making it more easily absorbed by the body. Fully reacted, chelated minerals do not dissasociate in the stomach’s acidic environment. They remain covalently bonded and can be properly absorbed and used by the body.

Fully reacted mineral ingredients, including our copper bisglycinate are up to four times more bioavailable, with less inhibition by other minerals, and have fewer potential side effects.


Copper is an essential mineral found throughout the body in small amounts, primarily in bones and muscles.  1

As a trace mineral, copper serves as a cofactor for enzymes, facilitating energy production for iron metabolism, connective tissue and red blood cell formation, collagen synthesis, and neurotransmitter production. 1, 2

  Copper is essential for the health and maintenance of the immune and nervous systems, as well as for brain and gene development. 3   In general most people consume enough copper in their daily diet, however some people may be at risk of low copper levels:  
  • People who take high doses of zinc supplements or use products, such as denture creams that contain zinc, may be at risk of a copper deficiency. Zinc limits copper absorption. People consuming zinc supplements and products should discuss copper supplementation with their healthcare practitioner. 1, 4 ‡
  • People with celiac disease may be at risk of low copper levels, due to challenges associated with celiac disease and intestinal malabsorption. 1, ‡

Why Choose Chelated Minerals

Up To

0 X

more bioavailable than non-fully reacted mineral ingredients


0 %

retention of mineral content compared to mineral salts over the shelf life

Less Than

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of the side effects
compared to mineral salts

Tolkien Z, Stecher L, Mander AP, Pereira DI, Powell JJ. Ferrous sulfate supplementation causes significant gastrointestinal side effects in adults: a systematic review and meta-analysis. PLoS One. 2015; 10: e0117383. 


Copper bisglycinate is made by binding bivalent copper with two glycine molecules. This ratio of copper to the amino acid glycine increase solubility, encouraging enhanced absorption in the small intestine and bloodstream.

Fully reacted, chelated minerals like copper bisglycinate do not disassociate in the stomach’s acidic environment. Instead, this form of copper remains covalently bonded and properly absorbed and used by the body.

Copper Bisglycinate
Research Data

Copper bisglycinate and copper are widely recognized for their positive health outcomes: 5, 6, 7 ‡

• A study of 51 post-menopausal women with osteoporosis and osteopenia suggested a deficiency in copper, magnesium, calcium, and zinc, might contribute to decreased bone density.
• Copper may have beneficial impacts on the absorption of iron, thereby potentially enabling hemoglobin and red blood cell production.
• A trial involving healthy American middle aged adults with moderately high cholesterol studied the impacts of copper supplementation on blood copper enzymes and markers in relation to heart health conditions. At the end of the eight week trial, results showed an increase in erythrocyte superoxide dismutase 1 and plasma ceruloplasmin.

Recommended Daily Allowance of Copper

The recommended daily allowance (RDA) of Copper: 1 ‡
    • Males and females aged 19 and older: 900 mcg
    • Females aged 19 and older who are pregnant: 1,000 mcg
    • Females aged 19 and older who are breast feeding: 1,300 mcg

Benefits of Copper Bisglycinate

The benefits of copper bisglycinate may include: 1, 2, 3, 8, 9 ‡

  • Production and development of red blood cells and hemoglobin
  • Positive for enzyme activation, enabling energy production and metabolism
  • Supports the body’s ability to absorb iron
  • Provides support for the growth and maintenance of the brain, heart, bones, connective tissues, and collagen
  • Provides nervous and immune system support
  • May act as an antioxidant, helping to limit free radical production

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

1 Copper: Fact Sheet for Health Professionals: National Institutes of Health (Accessed July 11, 2023)

2 Copper: Harvard T.H. Chan School of Public Health (Accessed July 11, 2023)

3 Copper: Fact Sheet for Consumers: National Institutes of Health (Accessed July 11, 2023)

4 Zinc: Mount Sinai (Accessed July 11, 2023)

5 Disilvestro, Robert & Joseph, Elizabeth & Zhang, Wenyi & Raimo, Adrienne & Kim, Young. (2012). A randomized trial of copper supplementation effects on blood copper enzyme activities and parameters related to cardiovascular health. Metabolism: clinical and experimental. 61. 1242-6. 10.1016/j.metabol.2012.02.002. (Accessed July 11, 2023)

6 Impact of Copper Limitation on Expression and Function of Multicopper Oxidases (Ferroxidases): Joseph R. Prohaska. Department of Biochemistry and Molecular Biology, University of Minnesota Medical School. (Accessed July 11, 2023)

7 Mahdavi-Roshan M, Ebrahimi M, Ebrahimi A. Copper, magnesium, zinc and calcium status in osteopenic and osteoporotic post-menopausal women. Clin Cases Miner Bone Metab. 2015 Jan-Apr;12(1):18-21. doi: 10.11138/ccmbm/2015.12.1.018. PMID: 26136790; PMCID: PMC4469220. (Accessed July 11, 2023)

8 The Link Between Copper and Nutrition: (Accessed July 11, 2023)

9 Health Benefits and Risks of Copper: MedicalNewsToday (Accessed July 11, 2023)