High Selenium Yeast 2000

NutraFeast® High Selenium Yeast 2000 is a selenium-enriched yeast derived from a non-GMO yeast strain. This high selenium yeast closely resembles the food-form of selenium available in dietary supplements.

High selenium yeast contains three organic selenium compounds: selenomethionine, selenocysteine, and methylselenocysteine. This form of selenium is more bioavailable and easier for the body to absorb, compared to other types of selenium.

Selenium is an essential nutrient for humans. This trace element is a constituent of over two dozen selenoproteins, with roles in DNA synthesis, thyroid hormone metabolism, reproduction, and protection from infection and oxidative damage.

What is NutraFeast® High Selenium Yeast 2000?

NutraFeast High Selenium Yeast 2000 is derived from a non-GMO yeast strain, with a selenium salt introduced during active, aseptic, aerobic fermentation.

During fermentation, the temperature, pH, and growth rate are closely regulated to ensure proper mineral uptake. The yeast cells take the selenium from the culture medium and

organically bind it to their natural protein matrix, producing a selenium complex from which approximately 70% is selenomethionine.

The resulting product is washed, separated, and held in refrigerated storage to ensure cell

viability and the absence of any “free” mineral. Prior to spray drying, the chilled yeast cream is pasteurized through a high temperature sterilization system to ensure it meets or exceeds established USDA food grade microbial requirements.

The composite sample collected during spray drying and packaging is analyzed for nutrient and microbial composition by external, independent, and certified laboratories. Once the product has met all QA/QC requirements, it is released for sale with a supporting Certificate of Analysis.

High Selenium Yeast Research Data‡

High selenium yeast is researched for its potential health benefits: 2, 3, 4, 6, 7, 8, 9, 10, 11‡


High selenium yeast is widely researched and studied to understand its bioavailability and absorption when compared to other forms of selenium. Research is positive for enhanced absorption of high selenium yeast across a diverse population.


Research supports the hypothesis that high selenium yeast exhibits lower toxicity and higher digestibility, absorption, and retention than other forms of selenium.


While the U.S. FDA does not endorse a specific format of selenium in infant formulas, evidence suggests that selenium-enriched yeast is more effectively absorbed and retained than other selenium forms.


Research and clinical trials support the potential positive impacts of selenium supplementation for cancer status.

The potential benefits of selenium yeast include: 3, 4, 8, 9, 10, 11, ‡

Lower toxicity and higher digestibility, absorption, and retention than other forms of selenium

May act as an antioxidant and free radical scavenger, thereby guarding against cellular oxidative stress

In general, selenium may provide immune system support

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*FDA Qualified Health Claim: Selenium may reduce the risk of certain cancers. Some scientific evidence suggests that consumption of selenium may reduce the risk of certain forms of cancer. However, FDA has determined that this evidence is limited and not conclusive.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

1 Selenium: Fact Sheet for Health Professionals: National Institutes of Health (Accessed September 13, 2023)

2 The use of high-selenium yeast to raise selenium status: how does it measure up? Rayman MP. Br J Nutr. 2004 Oct;92(4):557-73. doi: 10.1079/bjn20041251. PMID: 15522125. (Accessed September 13, 2023)

3 Digestibility and chemical species of selenium contained in high-selenium yeast. Yoshida M, Sugihara S, Suenaga T, Naito C, Fukunaga K, Tsuchita H.. J Nutr Sci Vitaminol (Tokyo). 2002 Oct;48(5):401-4. doi: 10.3177/jnsv.48.401. PMID: 12656215. (Accessed September 13, 2023)

4 Bioconversion of inorganic selenium to less toxic selenium forms by microbes: A review. Xingling Nie, et al. Front. Bioeng. Biotechnol., March 13, 2023 Volume 11-2023 doi: 10.3389/fbioe.2023.1167123 (Accessed September 13, 2023)

5 Selenium: Fact Sheet for Consumers: National Institutes for Health (Accessed September 13, 2023)

6 Selenium fortification of infant formulas: does selenium form matter? Lönnerdal B, Vargas-Fernández E, Whitacre M. Food Funct. 2017 Nov 15;8(11):3856-3868. doi: 10.1039/c7fo00746a. PMID: 28991311. (Accessed September 13, 2023)

7 Bügel S, Larsen EH, Sloth JJ, Flytlie K, Overvad K, Steenberg LC, Moesgaard S. Absorption, excretion, and retention of selenium from a high selenium yeast in men with a high intake of selenium. Food Nutr Res. 2008;52. doi: 10.3402/fnr.v52i0.1642. Epub 2008 Feb 12. PMID: 19109661; PMCID: PMC2596749. (Accessed September 19, 2023)

8 Decreased incidence of prostate cancer with selenium supplementation: results of a double-blind cancer prevention trial. Clark LC, Dalkin B, Krongrad A, Combs GF Jr, Turnbull BW, Slate EH, Witherington R, Herlong JH, Janosko E, Carpenter D, Borosso C, Falk S, Rounder J. Br J Urol. 1998 May;81(5):730-4. doi: 10.1046/j.1464-410x.1998.00630.x. PMID: 9634050. (Accessed September 13, 2023)

9 Influence of Selenium-enriched Yeast Supplementation on Biomarkers of Oxidative Damage and Hormone Status in Healthy Adult Males: A Clinical Pilot Study Karam El-Bayoumy, John P. Richie, Telih Boyiri, Despina Komninou, Bogdan Prokopczyk, Neil Trushin, Wayne Kleinman, Julie Cox, Brian Pittman, Steven Colosimo; Cancer Epidemiol Biomarkers Prev 1 November 2002; 11 (11): 1459–1465. (Accessed September 13, 2023)

10 Comparative effects of two different forms of selenium on oxidative stress biomarkers in healthy men: a randomized clinical trial. Richie JP Jr, Das A, Calcagnotto AM, Sinha R, Neidig W, Liao J, Lengerich EJ, Berg A, Hartman TJ, Ciccarella A, Baker A, Kaag MG, Goodin S, DiPaola RS, El-Bayoumy K. Cancer Prev Res (Phila). 2014 Aug;7(8):796-804. doi: 10.1158/1940-6207.CAPR-14-0042. Epub 2014 Jun 17. PMID: 24938534; PMCID: PMC4125492. (Accessed September 13, 2023)

11 The protective role of selenium on genetic damage and on cancer. El-Bayoumy K. Mutat Res. 2001 Apr 18;475(1-2):123-39. doi: 10.1016/s0027-5107(01)00075-6. PMID: 11295158. (Accessed September 13, 2023)

12 Hoffmann PR, Berry MJ. The influence of selenium on immune responses. Mol Nutr Food Res. 2008 Nov;52(11):1273-80. doi: 10.1002/mnfr.200700330. PMID: 18384097; PMCID: PMC3723386. (Accessed September 19, 2023)


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